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Biomarkers of endothelial activation/dysfunction in infectious diseases
发布于：2013年5月19日 文字：【大】【中】【小】
Virulence. 2013 Apr 19;4(6). [Epub ahead of print]
Biomarkers of endothelial activation/dysfunction in infectious diseases.
Source
Division of Infectious Diseases; Sandra A. Rotman Laboratory for Global Health; Mount Sinai Hospital-University Health Network; Toronto, ON Canada; Department of Medicine; University of Toronto; Toronto, ON Canada.
Abstract
Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic syndrome, severe malaria, and dengue hemorrhagic fever. Because endothelial activation often precedes overt endothelial dysfunction, biomarkers of the activated endothelium in serum and/or plasma may be detectable before classically recognized markers of disease, and therefore, may be clinically useful as biomarkers of disease severity or prognosis in systemic infectious diseases. In this review, the current status of mediators of endothelial cell function (angiopoietins-1 and -2), components of the coagulation pathway (von Willebrand Factor, ADAMTS13, and thrombomodulin), soluble cell-surface adhesion molecules (soluble E-selectin, sICAM-1, and sVCAM-1), and regulators of vascular tone and permeability (VEGF and sFlt-1) as biomarkers in severe infectious diseases is discussed in the context of sepsis, E. coli O157:H7 infection, malaria, and dengue virus infection.
内皮细胞功能紊乱参与到了众多潜在感染性疾病或者综合征，如败血症、感染性休克、溶血尿毒综合征疟疾和出血热的发病机制中。内皮细胞的活化一般早于内皮功能紊乱的发生，内皮细胞活化的血清或血浆生物学标记物在传统上认为的疾病的早期有可能被检测到。因此，这些生物学标记物或许可以用于提示临床感染性疾病的严重程度和预后。这篇综述在败血症、大肠杆菌感染、疟疾和登革病毒感染中讨论了内皮细胞功能的中介物(血管生成素1和2)，凝血系统成分(vWF，ADAMTS13，血栓调节蛋白)，游离的细胞表面粘附分子(游离E选择素，游离ICAM-1，游离VCAM-1)，以及严重感染的生物学标记物。